17-Hydroxycorticosteroid metabolism in liver disease.
نویسندگان
چکیده
منابع مشابه
The effect of intravenously-administered ACTH on plasma 17,21-dihydroxy-20-ketosteroids in normal individuals and in patients with disorders of the adrenal cortex.
The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific and quantitative tests of adrenal function (1). Changes in the 24-hour excretion values of urinary 17-ketosteroids and 17-hydroxycorticosteroids during ACTH administration have proved to be valuable indices of adrenocortical capacity (2, 3). With the development of technics for the chemical esti...
متن کاملEffect of SodiumSulfateon the Hydrolysisof 17-Hydroxycorticosteroid- andp-Nitrophenyl-glucuronides with fl-GlucuronidasePreparationsfrom BovineLiver
Previous papers dealt with the discovery that hydrolysis of 17-hydroxycorticosteroid glucuronides in urine with fi-glucuronidase preparations from bovine liver is increased by adding sodium sulfate to the incubation medium. Here, we conclude that sodium sulfate not only increases the activity of bovine liver /9-glucuronidase on 17-hydroxycorticosteroid glucuronides and p-nitrophenyl glucuronide...
متن کاملThe role of the liver and the adrenal in producing elevated plasma 17-hydroxycorticosteroid levels in surgery.
In another paper of this series (1) it was demonstrated that most patients undergoing surgery developed increased plasma levels of 17-hydroxycorticosteroids. Evidence was presented that these rises are mediated in part by extra-adrenal factors. The concept that extra-adrenal factors may affect adrenal steroid levels is not a new one but little evidence to support such a concept has been present...
متن کامل17-ketosteroid and 17-hydroxycorticosteroid excretion in patients with duodenal ulceration.
The 24-hour excretion of 17-ketosteroids and 17-hydroxycorticosteroids has been estimated in a series of male duodenal ulcer subjects and compared with that of 56 normal male controls. It has been found that both 17-ketosteroid and 17-hydroxycorticosteroid excretion is less in ulcer subjects than in the control group; these differences are not large but in the case of 17-hydroxycorticosteroids ...
متن کاملEndocrine-Manifestations of Cirrhosis and Liver Disease
The liver is involved in the synthesis and metabolism of many kinds of hormones, various abnormalities hormone levels are found in advanced liver disease. For example the liver is, extremely sensitive to changes in insulin or glucagon levels. The liver is the primary organ of iron storage is frequently involved, diabetes is common in patients with iron overload and may be seen in cirrhosis. Chr...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 33 11 شماره
صفحات -
تاریخ انتشار 1954